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So why is it important that this stuff binds so tightly to the AR?

 
Well, Androgen Receptors are found in both fat cells as well as muscle cells; they act on the AR in muscle cells to promote growth, and in the fat cells to affect fat burning.(9)(6) The stronger the androgen binds to the A.R, the higher the lipolytic (fat burning) effect on adipose (fat)tissue(9)(5). Unfortunately, that strong binding doesnt also automatically mean that it will elicit the strongest possible anabolic response, nor that the weakest bind will elicit a weak anabolic response.

Anadrol (oxymetholone) has the weakest bind to the AR possible (too low to be measured), and it produces a profound anabolic response, for example. Dianabol is simarly low, and produces a very good anabolic response. ARs are found in both muscle tissue as well as adipose tissue. When a muscles AR is stimulated, it can induce hypertrophy. When an adipose tissues AR is stimulated, through various related mechanisms, fat is lost. This is a gross oversimplification.

Whatever. All we need to know is that when you have a steroid that binds to the AR, it builds muscle and burns fat. And a steroid that binds very tightly to the AR will stimulate a lot of muscle synthesis and burn a lot of fat. A good example of this is Trenbolone. And since I mentioned Trenbolone, its worth further mentioning that MT is basically a 17aa (oral) version of (injectable) Trenbolone. AR binding and AR stimulation is not the only mechanism which stimulates anabolism, however. It is important to note that dbol has a very low AR binding ability and A50 has an AR binding ability which is too low to even measure!

Both are very potent oral steroids, though. So while its important, AR binding/stimulation is not the end all & be all of anabolism, although it is an important part. Dont be fooled by the anabolic/androgenic ratio of this (or any steroid), either. The anabolic/androgenic ratio of MT would suggest that it produces 120(+)x the anabolic and 60(+)x androgenic effect of Testosterone (which has a score of 100 and 100 respectively). If one were able to get a bottle of this stuff, I believe it would be best used as part of a cutting cycle, stacked with some injectables (testosterone, etc… ), but certainly no other orals. Its just too toxic.

Negma (the French company who brought Parabolan to the market, and then discontinued it) never pushed MT to gain approval as a commercially released item, since their original studies showed it to be highly toxic. Methyltrienolone is, of course, a 19Nor compound (as is Trenbolone)…Thus, it will effect your sexual drive and performance in a similar way to both Tren and Nandrolone, meaning that Temporary Impotence and/or a lack of libido is highly possible (aka Tren-Dick or Deca Dick)(10). Another problem with MT is that it is a progestin, and binds shockingly well to the progesterone receptor also (PgR) (3). As we know, progestins amplify estrogenic effects of Aromatizing drugs. Although MT doesnt aromatize, you will still need to worry about its ability to cause side-effects by amplifying the estrogenic issues caused by the other compounds you may be taking. How toxic is this stuff? Well, it was never commercially marketed for use in humans, and has been relegated to Steroid-Purgatory, to be used only in studies. Id probably rate it on around the same level as taking very high doses of halotestin or methyltestosterone.

And Id probably recommend that people keep doses of this product very low, much lower than recommended doses typical of the other 2 compounds I just mentioned (i.e. 500-750mcgs/day, for not much longer than 3-4 weeks). I have had the good fortune to discuss this product with the owner of an Underground Lab, and he had given out several samples of this stuff to athletes he knew, and they all kept records and got regular bloodwork done. People who were in the 2mg/day range developed highly elevated liver enzymes and Jaundice (yellowing of the eyes and skin).

They all recovered, and through trial and error, a 500-750mcg dose was found to be (*relatively) safe, and (*roughly) as effective as 150-225mgs of Trenbolone Acetate. For women, a possible side effect of MT is Virilization (development of male sexual characteristics), which is profound with this stuff (11), so it is entirely off limits for women to use.

You may want to take milk thistle with this compound, should you decide to try it, as well as (320mgs/day), ALA (500mgs per meal) and try some Pygeum Africanum (Permixon, the liposterolic extract of Serenoa)… stuff will all protect either your prostate or liver… in one study, it inhibited competitively the binding of Methyltrienolone to the cytosolic receptor of the rat prostate. Youll still need to get blood work done, avoid other orals (this includes drinking, or anything else which could tax your liver), and monitor your health closely.

This isnt a drug for novices, clearly, and is probably only useful for pre-contest bodybuilders. Ive only seen MT available from one Underground Lab, and it came in a 50ml bottle, which was 1mg/ml, and was priced at $100. This translates to roughly 100 doses, at a reasonable cost of fifty-cents per dose. And since you would never want to run this particular drug for longer than 3-4 weeks at a time (maybe it would have use in the last few weeks before a bodybuilding competition, but not much else), youll get to use one bottle in 4 different cycles. That makes it no less dangerous, just reasonably cheap.

Methyltrienolone Profile

[17beta-Hydroxy-17-methylestra-4,9,11-trien-3-one]
Molecular Weight: 284.3974
Formula: C19H24O2
Melting Point: N/A
Manufacturer: Negma (never released), Underground Labs
Effective dose: 500-750mcgs/day
Active Life: 4-6hours
Detection Time: Unknown (never tested in humans)
Anabolic/Androgenic Ratio (estimated):12,000+/6,000+

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