Dynabol 100mg/ml 10 ml – Medical Pharma Steroids in USA

Dynabol contains:100mg 100 mg / ml Methandrostenolone

Pharmacologic Category: Androgen.

Dosing: Adult 100mg every 24 hours. Deep intramuscular injection.

Dosing: Geriatric refer to adult dosing.

Dosing: Pediatric. has not been studied in pediatric population.

Dosing: Renal Impairment, no dosage adjustment provided in manufacturer’s labeling; use with caution due to propensity to cause edema.

Dosing: Hepatic Impairment, no dosage adjustment provided in manufacturer’s labeling; use with caution.

Use

Methandienone has anabolic and some androgenic properties. It has little progestogenic activity. Methandienone has been given orally as an anabolic drug.

Storage/Stability

Store in at room temperature in a dark and dry place.

Contraindications

Hypersensitivity to methandienone or any component of the formulation.

Warnings/Precautions

Gynecomastia: May cause Gynecomastia.

Hepatic effects: Prolonged use and/or high doses may cause peliosis hepatis or liver cell tumors, which may not be apparent until liver failure or intra-abdominal hemorrhage develops. Discontinue in case of cholestatic hepatitis with jaundice or abnormal liver function tests.

Venous thromboembolism: Venous thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE), have been reported with testosterone products. Evaluate patients with symptoms of pain, edema, warmth, and erythema in the lower extremity for DVT and those with acute shortness of breath for PE. Discontinue therapy if a venous thromboembolism is suspected.

Disease related concerns:

Breast cancer: Use with caution in patients with breast cancer; may cause hypercalcemia by stimulating osteolysis.
Edematous conditions: Use with caution in patients with conditions influenced by edema (eg, cardiovascular disease, migraine, seizure disorder, renal impairment); may cause fluid retention.

Hepatic impairment: Use with caution in patients with hepatic impairment.

Pregnancy Risk Factor X

Category X: Studies in animals or human beings have demonstrated fetal abnormalities, or there is evidence of fetal risk based on human experience, or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.

Pregnancy considerations

Use is contraindicated in women who are or may become pregnant; masculinization of the fetus has been reported.

Lactation: Excretion in breast milk unknown/not recommended.

Breast feeding considerations

It is not known if methandienone is excreted in breast milk. Due to the potential for serious adverse reactions in the nursing infant, breast-feeding is not recommended.

Adverse reactions

As with other 17α-alkylated compounds, methandienone is associated with hepatotoxicity and hepatic function should be monitored during therapy. It should probably be avoided in patients with hepatic impairment, and certainly if this is severe.

Frequency unknown.

Cardiovascular: Edema
Central nervous system: Depression, excitation, insomnia
Dermatologic: Acne (females and prepubertal males)
Also reported in females: Hirsutism, male-pattern baldness
Endocrine & metabolic: Electrolyte imbalances, glucose intolerance, gonadotropin secretion inhibited, gynecomastia, HDL decreased, LDL increased, libido changes
Also reported in females: Clitoral enlargement, menstrual irregularities
Genitourinary:
Prepubertal males: Increased or persistent erections, penile enlargement
Postpubertal males: Bladder irritation, epididymitis, impotence, oligospermia, priapism (chronic), testicular atrophy, testicular function inhibited
Hematologic: Prothrombin time increased, suppression of clotting factors
Hepatic: Alkaline phosphatase increased, ALT increased, AST increased, bilirubin increased, cholestatic jaundice, hepatic necrosis (rare), hepatocellular neoplasms, peliosis hepatis (with long-term therapy)
Neuromuscular & skeletal: CPK increased, premature closure of epiphyses (in children)
Renal: Creatinine excretion increased
Metabolism/Transport Effects: None known.

Drug interactions

Corticosteroids, Warfarin and Antidiabetic agents.

Test interactions

May suppress factors II, V, VII, and X; may increase PT; may decrease thyroxine-binding globulin and radioactive iodine uptake
Monitoring Parameters.

Liver function tests, cholesterol profile, hemoglobin/hematocrit; INR/PT in patients on anticoagulant therapy.

Children: Radiographs of left wrist and hand every 6 months (to assess bone maturation).

Adult females: Signs of virilization (deepening voice, hirsutism, acne, clitoromegaly); urine and serum calcium in women with breast cancer.

Dosage forms

Multi dosing vial: 100mg/10ml.
Multi dosing vial: 100mg/1 ml.
Anatomic Therapeutic Chemical (ATC) Classification.
A14AA03; D11AE01.

Mechanism of action

Methandrostenolone is a 17alpha-alkylated anabolic-androgenic steroid and a synthetic derivative of testosterone with a similar mechanism of action to other anabolic steroids.

Pharmacodynamics/Kinetics

Methandrostenolone is a modified form of testosterone. The resulting steroid also has a much weaker relative binding affinity for the androgen receptor than testosterone, but at the same time displays a much longer half-life and lower affinity for serum-binding proteins in comparison. These features allow methandrostenolone to be a very potent anabolic steroid in spite of a weaker affinity for receptor binding.

Metabolism: hepatic.
Half-life: 3-5 hours.

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