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Provir (Mesterolone) 50mg/tab 100 tabs – Medical Pharma Steroid in USA


Pharmacologic Category


Dosing: Adult

50mg every days for duration of 4-8 weeks.

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

No information in pediatric population available.

Dosing: Renal impairment

No dosage adjustment provided in manufacturer’s labeling; use with caution due to propensity to cause edema.

Dosing: Hepatic impairment

No dosage adjustment provided in manufacturer’s labeling; use with caution.

Provir (Mesterolone) 50mg/tab 100 tabs – Medical Pharma Steroid in USA


Provir (Mesterolone) Use: Labeled indications

Has been used in the treatment of advanced malignant neoplasms of the breast in postmenopausal.


Keep at room temperature 15-30°C (59-86°F). Do not freeze. This drug should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Warming and shaking the vial should re-dissolve any crystals that may have formed during storage at temperatures lower than recommended. Protect from sun light


Hypersensitivity to Mesterolone or any component of the formulation.

Men with carcinomas of the breast or with known or suspected carcinomas of the prostate; women who are or may become pregnant.

Documentation of allergenic cross-reactivity for androgens is limited. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty.


• Gynecomastia: May cause Gynecomastia.

• Hepatic effects: Prolonged use and/or high doses may cause peliosis hepatis or liver cell tumors, which may not be apparent until liver failure or intra-abdominal hemorrhage develops. Discontinue in case of cholestatic hepatitis with jaundice or abnormal liver function tests.

• Venous thromboembolism: Venous thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE), have been reported with testosterone products. Evaluate patients with symptoms of pain, edema, warmth, and erythema in the lower extremity for DVT and those with acute shortness of breath for PE. Discontinue therapy if a venous thromboembolism is suspected.

Disease related concerns:

• Breast cancer: Use with caution in patients with breast cancer; may cause hypercalcemia by stimulating Osteolysis.

• Edematous conditions: Use with caution in patients with conditions influenced by edema (eg, cardiovascular disease, migraine, seizure disorder, renal impairment); may cause fluid retention.

• Hepatic impairment: Use with caution in patients with hepatic impairment.

Pregnancy risk factor


Category X: Studies in animals or human beings have demonstrated fetal abnormalities, or there is evidence of fetal risk based on human experience, or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.

Pregnancy considerations

Use is contraindicated in women who are or may become pregnant; masculinization of the fetus has been reported.


Excretion in breast milk unknown/not recommended

Breast feeding considerations

It is not known if drostanolone is excreted in breast milk. Due to the potential for serious adverse reactions in the nursing infant, breast feeding is not recommended.

Adverse reactions

Frequency unknown.

Cardiovascular: Edema.

Central nervous system: Depression, excitation, insomnia.

Dermatologic: Acne (females and prepubertal males).

Also reported in females: Hirsutism, male-pattern baldness.

Endocrine & metabolic: Electrolyte imbalances, glucose intolerance, gonadotropin secretion inhibited, gynecomastia, HDL decreased, LDL increased, libido changes.

Also reported in females: Clitoral enlargement, menstrual irregularities


Prepubertal males: Increased or persistent erections, penile enlargement.

Postpubertal males: Bladder irritation, epididymitis, impotence, oligospermia, priapism (chronic), testicular atrophy, testicular function inhibited.

Hematologic: Prothrombin time increased, suppression of clotting factors.

Hepatic: Alkaline phosphatase increased, ALT increased, AST increased, bilirubin increased, cholestatic jaundice, hepatic necrosis (rare), hepatocellular neoplasms, peliosis hepatis (with long-term therapy).

Neuromuscular & skeletal: CPK increased, premature closure of epiphyses (in children).

Renal: Creatinine excretion increased.

Metabolism/Transport effects

None known.

Drug interactions

Corticosteroids, Warfarin and Antidiabetic agents.

Test interactions

May suppress factors II, V, VII, and X; may increase PT; may decrease thyroxine-binding globulin and radioactive iodine uptake

Monitoring parameters

Liver function tests, cholesterol profile, hemoglobin/hematocrit; INR/PT in patients on anticoagulant therapy.

Children: Radiographs of left wrist and hand every 6 months (to assess bone maturation).

Adult females: Signs of virilization (deepening voice, hirsutism, acne, clitoromegaly); urine and serum calcium in women with breast cancer.

Dosage forms

10 mg and 20 mg pills of steroid

Anatomic Therapeutic Chemical (ATC) Classification

⦁ A14 (no specific code ever assigned).

Mechanism of Action

Synthetic derivative of dihydrotestosterone, producing an anabolic effect and promoting protein synthesis as well as creating positive nitrogen balance in humans. Does not aromatize to estrogens.


Metabolism: Hepatic

Elimination: Kidney

Half-life: 2-3 days

Local anesthetic/Vasoconstrictor precautions

No information available to require special precautions.

Effects on dental treatment

No significant effects or complications reported.

Effects on bleeding

No information available to require special precautions.

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