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Methyltestosterone is an oral testosterone hormone, the first oral testosterone preparation and the first C17-alpha alkylated (C17-aa) steroid ever made.

 
The compound has appeared over the years under numerous trade names, but perhaps the most well known Methyltestosterone compound of all time was Ciba’s Metandren. Ciba’s Methyltestosterone, while oral, was actually a sublingual form, which enhanced the bioavailability of the testosterone hormone.

In fact, this form doubles the bioavailability compared to a tablet version and enables the individual to reach peaked testosterone levels in an hour. If Methyltestosterone is used in tablet form, it can take approximately two hours for peak levels to be reached, not to mention carrying a much lower potency.

While Ciba’s Metandren was a successful product, this particular and most well known brand is no longer available. Currently, generic brands are primary as well as several underground lab preparations. The only name brand pharmaceutical based pure Methyltestosterone for several years has come out of Greece in Teston.

While Methyltestosterone is not as common as it once was on the pharmaceutical market, it is still used in some areas around the world. Oddly enough, while it has been pulled from many markets, while many U.S. physicians rarely prescribe it Methyltestosterone is in high supply on the U.S. pharmaceutical market. The compound has been used to treat low testosterone and andropause in men, as well as cryptorchidism.

It has also been somewhat successful in some breast cancer treatment plans, treating excess lactation post pregnancy and osteoporosis. Most interestingly, Methyltestosterone has had a fair amount of success in treating menopause by enhancing often lost libido and energy levels that often diminish during this stage of life for many women. While Methyltestosterone has enjoyed success in menopause treatment in the modern era, most women are now prescribed other testosterone forms. Creams and gels are perhaps the most common. Testosterone and progesterone mixed creams have been highly successful as well as subcutaneous implant pellets like Testopel.

While it has held a fair amount of success, Methyltestosterone is considered one of the more controversial testosterone medications in traditional medicine. This controversy largely surrounds its hepatotoxic nature, which does not exist with other testosterone compounds. Further, unlike most testosterone compounds you will rarely find Methyltestosterone being used in performance enhancing circles. Methyltestosterone like all testosterone compounds carries an estrogenic nature, but this form generally carries it at a far pronounced level and is simply a poor choice for most athletes.

Methyltestosterone Functions & Traits:

Methyltestosterone is a pure testosterone hormone that has an added methyl group attached in order for the hormone to survive oral ingestion. The methyl group is attached at the 17th carbon position officially classifying Methyltestosterone as a C17-aa anabolic androgenic steroid. Like all testosterone hormones, Methyltestosterone carries an anabolic rating of 100 as well as an androgenic rating of 100. However, due to the C17-aa alteration, its translating anabolic activity will be significantly less than most testosterone compounds.

On a functional basis, Methyltestosterone provides testosterone to the body that it may be lacking. Due to its low bioavailability and potent estrogenic nature that we’ll cover in the side effects section, this makes it a poor choice for performance. However, we will be able to make one performance exception when we look at the effects of Methyltestosterone.

As a pure testosterone hormone, Methyltestosterone is a perfect synthetic model of the primary male androgen testosterone. While synthetic in nature, once in the body the body will make no distinguishing difference in it and the testosterone it naturally produces. While the primary male androgen, women also produce and need testosterone, which often diminishes during menopause. However, while they need the hormone men need approximately ten times that of women.

Due to Methyltestosterone being testosterone, it will perform all the traits of the naturally produced hormone. The testosterone hormone greatly affects our physical and sexual wellbeing, and to a degree, even our mental function. When levels become low each and every one of these areas can be negatively affected. Conversely, when low levels are combated with compounds like Methyltestosterone functions return to where they’re supposed to be. For more information on the functions and traits of testosterone, see any of the primary testosterone profiles – Testosterone Cypionate, Testosterone Enanthate, Testosterone Propionate or Testosterone Suspension.

Effects of Methyltestosterone:

The effects of Methyltestosterone are brought on by simply increasing the amount of circulating androgens through exogenous use of this hormone. This could be done to combat a condition brought on by low levels, or it could be to enhance androgen levels above baseline levels to help combat another condition. However, while both are possible the former is the most common in a medical setting. By supplementing with this androgen, the effects of Methyltestosterone should enhance the individual’s sex drive and boost energy levels that are often in decline with low levels of the hormone in the body. This is where the effects of Methyltestosterone will benefit the menopause or andropause patient greatly. Such conditions will also be the most common point of use for this particular version of the testosterone hormone.

For the purpose of performance enhancement, the effects of Methyltestosterone will normally be found lacking. For a true performance boost it would require long term high dose use and due to this steroid’s hepatotoxicity it simply isn’t a viable option. We will, however, find the steroid is nowhere near as toxic as many have inaccurately believed, but it still won’t be viable for long term performance use.

Where the effects of Methyltestosterone could primarily benefit the athlete will be in a pure androgenic sense, not anabolic. By supplementing for short periods of time with a significant dose, the high level of androgenic activity could increase aggression significantly.

This could be beneficial to power lifters and other strength athletes prior to competition. However, when looking at the effects of Methyltestosterone in this regard there is something we need to clear up. There is no anabolic steroid that can alter an individual’s personality or take away his ability to distinguish from right or wrong. A non-violent person cannot turn into a violent animal due to any anabolic steroid use.

With most anabolic steroids, the aggression factor will not be a factor at all, but with this particular androgen, as is with the steroid Halotestin an enhanced aggressive nature is possible. It’s also important to note that aggression in of itself is not a bad thing. What we do with aggression is what makes it right or wrong.

Enhanced aggression can be extremely beneficial when it’s used for the right purpose, such as competitions that surround strength. Some bodybuilders may also find the effects of Methyltestosterone beneficial in this regard right before competition to help them through the final stages when energy levels are often low. However, due to the potent estrogenic activity of Methyltestosterone there are normally better options.

An important note on the effects of Methyltestosterone as it pertains to aggression – if you are already a violent individual this is a steroid you should avoid. If you are a violent individual the enhanced aggression will only make you more aggressively violent. If you are a sane individual, the effects of Methyltestosterone will not change this in any way and you should still display your same level of self control.

Side Effects of Methyltestosterone:

The testosterone hormone is generally a very side effect friendly hormone for most adult men. However, the side effects of Methyltestosterone can be a bit stronger and a little harsher than most testosterone compounds. This will hold true with most areas potentially affected by testosterone in a negative way. In order to help you understand the possible side effects of Methyltestosterone, we have broken them down into their separate categories along with all the information you’ll need.

Estrogenic: The possible side effects of Methyltestosterone include those of an estrogenic nature. Such effects are due to the testosterone hormone converting to estrogen due to its interaction with the aromatase enzyme. Methyltestosterone aromatizes much slower than most testosterone compounds due to the 17-alpha methylation of the hormone, but rather than converting to estradiol it converts to methylestradiol.

Methylestradiol is an extremely powerful estrogenic hormone and this can lead to gynecomastia and excess water retention. All testosterone hormones can lead to these effects, but Methyltestosterone carries a higher probability of such effects occurring. In fact, the estrogenic side effects of Methyltestosterone can appear seemingly overnight making the use of an anti-estrogen imperative when men use this testosterone.

When combating the estrogenic side effects of Methyltestosterone, you have two options, Selective Estrogen Receptor Modulators (SERM’s) or Aromatase Inhibitors (AI’s). SERM’s like Tamoxifen Citrate (Nolvadex) function by binding to the estrogen receptors thereby preventing the estrogen hormone from binding and activating. AI’s like Letrozole (Femara) function by inhibiting the aromatase process thereby reducing serum estrogen levels. AI’s are by far the most effective, but unfortunately, they can have a negative impact on cholesterol. Testosterone, as we’ll soon see can also have a negative effect on cholesterol and this is enhanced when an AI is present. Further, the total affect of Methyltestosterone on cholesterol is much greater than most testosterone forms.

Due to the potential cholesterol complications, while SERM’s aren’t as effective they should be your first choice when combating the estrogenic side effects of Methyltestosterone. They won’t be strong enough for some men but for some they will and they will have no negative effect on cholesterol. In fact, SERM’s will actually promote healthier cholesterol due to their estrogen like activity in the liver.

Androgenic: The side effects of Methyltestosterone can include those of an androgenic nature. Such effects include acne, accelerated hair loss in those predisposed to male pattern baldness and body hair growth. These effects are due to the hormone being metabolized by the 5-alpha reductase enzyme, which causes a reduction of the hormone to methyldihydrotestosterone (MDHT).

However, such effects are highly dependent on genetics and individual sensitivity, but more men will have a problem with the androgenic side effects of Methyltestosterone than most testosterone forms. For this reason, some may find the use of a 5-alpha reductase inhibitor like Finasteride to be beneficial. A 5-alpha reductase inhibitor will reduce the androgenicity of the hormone, it won’t reduce it completely, but it will be significant.

Women must also concern themselves with the androgenic side effects of Methyltestosterone. This steroid carries a strong potential for virilization, which can include body hair growth, a deepening of the vocal chords and clitoral enlargement. Low doses of the hormone mixed with esterified estrogens can reduce the probability of virilization such as through the use of the compound Estratest, which contains a very low dose of Methyltestosterone along with the necessary esterified estrogen.

However, most women are encouraged to discontinue use immediately if virilization symptoms begin to show. If use is discontinued at the onset of symptoms they will fade away rapidly. If the symptoms are ignored they may become irreversible. Due to the virilization potential of this steroid, which is strong, no woman should use Methyltestosterone for performance purposes. This steroid should only be used in very low doses in specific therapeutic cases.

Cardiovascular: The side effects of Methyltestosterone can include high blood pressure, but this is often controlled when the individual controls water retention. High levels of water retention are notorious for promoting high blood pressure. If Water retention is controlled most will not have an issue; however, high blood pressure is still possible but unlikely.

Like all testosterone compounds Methyltestosterone can negatively affect cholesterol. Most testosterone hormones can have a slight impact on HDL cholesterol providing a moderate amount of suppression. However, even when supraphysiological doses of testosterone are used this will normally not have a strong, negative impact on cholesterol. Then we have Methyltestosterone and it can significantly suppress HDL cholesterol and increase LDL cholesterol by approximately 30% in both categories. This greater negative effect on cholesterol is due to this testosterone form being a C17-aa anabolic steroid, a trait other testosterone hormones do not typically carry.

Further, the use of an AI may also lead to a greater level of HDL suppression. Due to the potential negative effects on cholesterol those who supplement with Methyltestosterone will necessarily need to put some effort into controlling their cholesterol levels. This is an important factor in all anabolic steroid use and in life in general, but extra attention should be given when this steroid is used.

It will be important to keep an eye on your cholesterol levels. The individual should also limit his intake of saturated fat and simple sugars and make omega fatty acids a regular part of his diet. Daily fish oil supplementation is advised as it a cholesterol antioxidant supplement.

Testosterone: Most all anabolic androgenic steroids will suppress natural testosterone production. However, the rate of suppression is dependent on the steroid in question and can also be affected by the total dose. While Methyltestosterone is significantly suppressive, the individual should be able to avoid a low testosterone condition since the Methyltestosterone will be providing all the testosterone he needs. However, once use is discontinued he will be in a low state.

Once all use is discontinued, most men are encouraged to implement a Post Cycle Therapy (PCT) plan. This will stimulate natural production and greatly reduce the risk of a low testosterone condition.

Those who are healthy will be able to recover without a PCT plan, but it will take a lot longer and can be damaging to their health when a low level is maintained for a decent amount of time. There truly is no reason for forgoing a PCT plan outside two exceptions. Women will not need to implement a PCT plan. Men who suffer from low testosterone will also not need a PCT plan as such a condition will require continuous and indefinite testosterone therapy of some kind in order to keep the condition at bay.

Hepatotoxicity: Methyltestosterone carries a hepatotoxic nature, but nowhere near what many assume. All C17-aa steroids are toxic to the liver but the level of toxicity varies from one C17-aa steroid to the next. Therapeutic level doses will burden the liver with some stress, liver enzyme values will increase with use, but if the liver was healthy to begin with no damage should be done. Performance level doses will increase the stress to the liver, but we will still find the total level of toxicity to be less than many C17-aa anabolic steroids. In fact, the hepatotoxicity of Methyltestosterone will not match most C17-aa steroids.

In order to protect the liver during use, again it is important that the liver is healthy before use begins. Use should also not surpass eight weeks with six weeks being enough for most users. If the individual is healthy enough for use, he must avoid all excess alcohol consumption. Excess consumption will greatly stress the liver alone and when Methyltestosterone is added it will only amplify the stress.

Avoiding all over the counter medications when possible is also advised as many over the counter medications carry strong hepatotoxic natures. Such medications should only be used when absolutely necessary. The use of a liver detoxification supplement is also advised. If these recommendations are followed, while liver enzyme values will increase with use, if no underlying issues exist they will return to normal once use is discontinued and no damage to the vital organ will be done.

Methyltestosterone Administration:

In a therapeutic setting, standard male Methyltestosterone doses will fall in the 10-40mg per day range. This is a wide range in dosing, and it is impossible to predict where the individual will fall until his full condition is examined. It is not uncommon for the starting dose to be 40mg per day or close to it and then a lower dose used for maintenance. Use may also surpass the recommended 6-8 week range if lab results show the individual is maintaining proper liver and lipid health.

In a performance setting, standard male Methyltestosterone doses will normally fall in the 40-50mg per day range for 6-8 weeks of use. However, keep in mind that very few athletes will benefit from this steroid’s use and will normally find there are better alternatives.

Female Methyltestosterone doses will be a little different than male plans and in no case is there any recommended female performance level plan. In a therapeutic setting, 2.5mg per day along with esterified estrogen is standard. This is where Estratest tablets will be useful as they are a mixture of Methyltestosterone and esterified estrogen.

Methyltestosterone Availability:

Methyltestosterone is widely available on the pharmaceutical market and should be one of the most affordable anabolic steroids you ever find. However, it is not commonly sold on the black market due to its low level of performance use, but there is an exception. Many underground labs will use Methyltestosterone for all their oral anabolic steroids due to the hormone being so cheap. It’s not uncommon for a lab to label a steroid Anadrol, Dianabol or Winstrol or any other oral steroid you can think of and it actually be Methyltestosterone. An experienced anabolic steroid user will be able to spot this fairly easily, but someone who lacks any steroid knowledge may find himself under this scam if he isn’t careful. You must thoroughly research your supplier and brand in question before you make a purchase.

Methyltestosterone Reviews:

Methyltestosterone is one of the more unique testosterone compounds on the market. In fact, while varying testosterone compounds all carry a bit of a unique nature, in truth most are fairly identical outside of Methyltestosterone. Methyltestosterone’s lacking anabolic power, higher translatable androgenicity and estrogen traits alone make it unique. When we consider its C17-aa nature, this truly separates if from most testosterone compounds.

While Methyltestosterone is a bit unique in nature, it is also a bit unique in use. While there is a performance purpose for some most will find there are far better options when we examine effectiveness. As a medicinal testosterone, for the male patient, while effective it will often be found lacking compared to most testosterone compounds. Most men will be far more pleased with injectable testosterone or testosterone gels, and in some cases, testosterone implant pellets. The only true benefit of this hormonal compound appears to be in female use to combat the effects of menopause, but even then only when used in low doses with esterified estrogen. It does appear to hold a lot of potential in this category of use and may become a regular part in many female hormone replacement therapy plans. However, in the modern age it is far from the only option and as this field of medicine continues to grow it too may become obsolete in the near future.

Methyltestosterone Profile

[17alpha-methyl-4-androstene-3-one,17b-ol]
Molecular Weight: 302.4558
Formula: C20 H30 O2
Melting Point: 162-167
Manufacturer: Most Major Pharmaceutical Companies
Effective dose: (Men) 25-100mgs/day; (Women) N/A
Active Life: 6-8 hours
Detection Time: 4-6 weeks
Anabolic /Androgenic Ratio (Range): 94-130/115-150

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