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Viagra (Sildenafil) and Cialis (Tadalafil) use in bodybuilding

Viagra (Sildenafil) and Cialis (Tadalafil) use in bodybuilding where to buy steroids

Viagra y Cialis


We’re sure you’ve heard about Viagra (sildenafil) or Cialis (tadalafil) before, the famous blue pill used for erection dysfunction, well this famous pill is starting to be used in the bodybuilding community, quiet recently, considering that the WADA (World Anti-Doping Agency) hasn’t banned it yet.

How does Viagra and Cialis work?

These medications do not directly cause penile erections, but affect the response to sexual stimulation. The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil enhances the effect of NO by inhibiting phosphodiesterase type 5 (PDE-5), which is responsible for degradation of cGMP in the corpus cavernosum; when sexual stimulation causes local release of NO, inhibition of PDE-5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. [2]

That way it prolongs or boosts the normal vasodilation in the penis (and other parts of the body)

How would it help in bodybuilding?

As a vasodilator, it doesn’t’ just dilate blood vessels in the penis or the lungs, it does so everywhere in the body, in fact it is not extremely rare that susceptible individuals feel dizzy and get hypotension with these medications, mostly elder patients. So this vasodilation happens within the muscles too, which THEORETICALLY would help bringing nutrients, medications, oxygen and everything a muscle usually needs to grow.

There are multiple reports of sildenafil being effective in increasing muscle blood flow and exercise performance.

A project from two scientist from Standford university and University of Miami plans to find this out. [3]

A study from 2014 showed that sildenafil (Viagra) improve muscle oxygenation and may be helpful in patients with claudication (a form of chronic arterial disease in which patients do not get enough blood flow to their legs, making it hard to walk because of pain, as literally their legs muscles are infarcting for the insufficient blood blow). [4]

Another study from 2014 in mice, showed that “sildenafil had anxiogenic effects in young as well as aged mice, but it enhanced locomotor activity only in the young mice in the elevated plus maze test. Thus, sildenafil seems to exert different effects on anxiety and locomotion in young and aged animals.”. [5]

In 2013 a reported case of a 57 year old patient with claudication that started using sildenafil for erectile dysfunction and “noted that his walking distance was more than doubled on the mornings after taking sildenafil, and he has been using sildenafil primarily for shopping trips since that time.” [6].

An interesting 2004 study made in the Mount Everest, showed that sildenafil improved performance at high altitudes, in their conclusions they mention “Sildenafil reduces hypoxic pulmonary hypertension at rest and during exercise while maintaining gas exchange and systemic blood pressure. To the authors’ knowledge, sildenafil is the first drug shown to increase exercise capacity during severe hypoxia both at sea level and at high altitude.” [7]

And finally, one of the most interesting studies, was a study in mice, published in 2013 were they investigated the effects of sildenafil in the cardiac muscle of rats during prolonged moderate exercise training, and the authors conclude “Our data confirm the beneficial effects of a moderate and prolonged training on cardiovascular and skeletal systems and document the positive and negative effects of sildenafil on these tissues at doses higher than those used in clinical practice. This report may impact on the use of sildenafil as a substance able to influence sports performance.” [8].

So after all this evidence we can think that it is highly probable that sildenafil or tadalafil may work for bodybuilders, probably there will never be a study specific in bodybuilders, so we may have to stick with this scarce evidence, at least for now.

Bibliography

1-. WADA prohibited list.
( https://www.wada-ama.org/en/resources/science-medicine/prohibited-list )
2-. Lexi-Comp. Sildenafil.
( http://online.lexi.com/lco/action/api/find/globalid/6951? )
3-. PROJECT REVIEW. Can Sildenafil Improve Exercise Performance at Moderate Altitude?. K.A. Jacobs (University of Miami, Florida, USA), A.L. Friedlander (Stanford University, California, USA).
(https://wada-main-prod.s3.amazonaws.com/resources/files/t06c01af_friedlander-jacobs.pdf )
4-. Am J Physiol Regul Integr Comp Physiol. 2014 Aug 15;307(4):R396-404. doi: 10.1152/ajpregu.00183.2014. Epub 2014 Jun 18. Sildenafil improves skeletal muscle oxygenation during exercise in men with intermittent claudication. Roseguini BT, Hirai DM, et al.
(http://www.ncbi.nlm.nih.gov/pubmed/24944249 )
5-. Med Sci Monit Basic Res. 2014 Feb 5;20:15-21. doi: 10.12659/MSMBR.890280. Sildenafil enhances locomotor activity in young mice and exerts anxiogenic effects in both young and aged mice. Demirci D, Mutlu O, Akar F, Komsuoglu Celikyurt I, Ulak G.
(http://www.ncbi.nlm.nih.gov/pubmed/24500039 )
6-. Scott Med J. 2013 Aug;58(3):e7-9. doi: 10.1177/0036933013496919. Improvement in symptoms of peripheral arterial disease with sildenafil therapy. Turtle EJ, Drummond ID, Webb DJ.
(http://www.ncbi.nlm.nih.gov/pubmed/23960069 )
7-. Ann Intern Med. 2004 Aug 3;141(3):169-77. Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial. Ghofrani HA, Reichenberger F, et al.
(http://www.ncbi.nlm.nih.gov/pubmed/15289213 )
8-. PLoS One. 2013 Jul 29;8(7):e69954. doi: 10.1371/journal.pone.0069954. Print 2013. Effects of sildenafil on the gastrocnemius and cardiac muscles of rats in a model of prolonged moderate exercise training. Rinaldi B, Donniacuo M, Sodano L, et al.
(http://www.ncbi.nlm.nih.gov/pubmed/23922868 )

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