Deposteron Testosterone Cypionate for sale 250mg/ml 10 ml M P Buy in USA

Deposteron 250 Testosterone Cypionate 250mg/ml 10 ml (Testosterone Cypionate) – Medical Pharma Steroids in USA

What is Deposteron?

Deposteron is a brand name for a medication that contains testosterone, a hormone that the human body naturally produces. Doctors use it as hormone replacement therapy when men have testosterone deficiency or low testosterone levels. Medical professionals typically administer Deposteron through intramuscular injections, and it helps restore normal testosterone levels. This can bring about various positive effects on a person’s health and well-being, including increased energy levels, muscle mass, and an enhanced mood. It is important to use Deposteron only under the supervision and prescription of a qualified healthcare provider, as improper use can lead to side effects and health risks.

Desposteron  Testosterone for sale  C dosing: Adult

Hypogonadism or hypogonadotropic hypogonadism (males):

IM: 50 to 400 mg every 2 to 4 weeks (FDA-approved dosing range); 75 to 100 mg/week or 150 to 200 mg every 2 weeks.

Delayed puberty (males):

IM: 50 to 200 mg every 2 to 4 weeks for a limited duration.

Dosing: Geriatric

Refer to adult dosing.

Dosing from Deposteron 250 : Pediatric

Delayed puberty (adolescent males):

IM: Refer to adult dosing.

Hypogonadism or hypogonadotropic hypogonadism (adolescent males):

IM: Refer to adult dosing.

Dosing: Renal impairment

There are no dosage adjustments (has not been studied). Use with caution; may enhance edema formation. Testosterone cypionate is contraindicated in serious renal disease.

Dosing: Hepatic impairment

There are no dosage adjustments (has not been studied). Use with caution; may enhance edema formation. Testosterone cypionate is contraindicated in serious hepatic disease.

Use: Labeled indications from Deposteron

Injection: Androgen replacement therapy in the treatment of delayed male puberty; male hypogonadism (primary or hypogonadotropic); inoperable metastatic female breast cancer (enanthate only).

Administration from Deposteron 250: IM

Deposteron is administered by deep IM injection into the gluteal muscle.

Testosterone enanthate or testosterone cypionate: Warm to room temperature; shaking vial will help redissolve crystals that have formed after storage.

Hazardous agent; use appropriate precautions for handling and disposal (NIOSH 2014 [group 3]).

Storage/Stability

Store at room temperature. Protect from light.

Preparation for administration for Deposteron 250

Injection:

Testosterone enanthate, testosterone cypionate: Warm to room temperature; shaking vial will help redissolve crystals that have formed after storage.

Contraindications with Deposteron 250

Hypersensitivity to testosterone or any component of the formulation; males with carcinoma of the breast or known or suspected carcinoma of the prostate; women who are breast-feeding, pregnant, or who may become pregnant.

Depo-Testosterone: Also contraindicated in serious hepatic, renal, or cardiac disease

Documentation of allergenic cross-reactivity for androgens is limited. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty.

Warnings/Precautions for Deposteron 250

Concerns related to adverse effects:

Cardiovascular events: Studies have suggested an increased risk of cardiovascular events among groups of men prescribed testosterone therapy (Basaria, 2010; Finkle, 2014; Vigen, 2013). The Endocrine Society suggests it may be prudent to avoid testosterone therapy in men who have experienced a cardiovascular event (eg, MI, stroke, acute coronary syndrome) in the past six months (The Endocrine Society, 2014). These risks are currently under review by the FDA (Drug Safety Communication, 2014).

Dyslipidemia: May alter serum lipid profile; use caution with history of MI or coronary artery disease.

Gynecomastia: May cause Gynecomastia.

Hepatic effects: Prolonged use of high doses of oral androgens has linked serious hepatic effects (such as peliosis hepatis, hepatic neoplasms, cholestatic hepatitis, jaundice) to them. Prolonged use of intramuscular testosterone enanthate has linked it to multiple hepatic adenomas. Discontinue therapy if signs or symptoms of hepatic dysfunction (such as jaundice) develop.

Hypercalcemia: May cause hypercalcemia in patients with prolonged immobilization or cancer.

Polycythemia: May increase hematocrit requiring dose adjustment or discontinuation. Discontinue therapy if hematocrit exceeds 54%; may reinitiate at a lower dose (Bhasin, 2010).

Prostate cancer: May increase the risk of prostate cancer.

Spermatogenesis: Large doses may suppress spermatogenesis.

Venous thromboembolism: Venous thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE), have been reported with testosterone products. Evaluate patients with symptoms of pain, edema, warmth, and erythema in the lower extremity for DVT and those with acute shortness of breath for PE. Discontinue therapy if a venous thromboembolism is suspected.

Disease-related concerns :

Benign prostatic hyperplasia (BPH): Androgens may worsen BPH; patients may also be at an increased risk of prostate cancer. Discontinue therapy if urethral obstruction develops in patients with BPH (use a lower dose if restarted). Withhold therapy pending urological evaluation in patients with a palpable prostate nodule or induration, PSA >4 ng/mL, or PSA >3 ng/mL in men at high risk of prostate cancer (Bhasin, 2010).

Diseases exacerbated by fluid retention: Use with caution in patients with diseases that may be exacerbated by fluid retention, including cardiac, hepatic, or renal dysfunction; testosterone may cause fluid retention.

Sleep apnea: May potentiate sleep apnea in some male patients (obesity or chronic lung disease).

Concurrent drug therapy issues:

Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Consult drug interactions database for more detailed information.

Special populations:

In the elderly population, caution should be exercised when considering this medication due to the potential risk of cardiac problems and contraindications for men with prostate cancer. In general, it is advisable to avoid its use in older adults, except in cases of moderate-to-severe hypogonadism as per the Beers Criteria. Furthermore, elderly patients may face an increased risk of prostatic hyperplasia, prostate cancer, fluid retention, and transaminase elevations.

Pediatric: May accelerate bone maturation without producing compensatory gain in linear growth in children; in prepubertal children perform radiographic examination of the hand and wrist every 6 months to determine the rate of bone maturation and to assess the effect of treatment on the epiphyseal centers. Gels, solution, transdermal, and buccal systems have not been evaluated in males <18 years of age; safety and efficacy of injection have not been established in males <12 years of age.

Women: During treatment for metastatic breast cancer, women should be monitored for signs of virilization; discontinue if mild virilization is present to prevent irreversible symptoms.

Dosage from Deposteron 250 for specific issues:

Benzyl alcohol and derivatives: Some dosage forms may contain benzyl alcohol; we have associated large amounts of benzyl alcohol (≥99 mg/kg/day) with potentially fatal toxicity in neonates, known as “gasping syndrome.” This syndrome comprises metabolic acidosis, respiratory distress, gasping respirations, CNS dysfunction (including convulsions, intracranial hemorrhage), hypotension, and cardiovascular collapse (AAP, 1997; CDC, 1982); some data suggests that benzoate displaces bilirubin from protein binding sites (Ahlfors, 2001); avoid or use dosage forms containing benzyl alcohol with caution in neonates. See manufacturer’s labeling.

⦁ Castor oil: Some products may contain castor oil.

⦁ Soy: Some testosterone products may be chemically synthesized from soy.

Special handling from Deposteron:

⦁ Hazardous agent: Use appropriate precautions for handling and disposal (NIOSH 2014 [group 3]).
Other warnings/precautions:

⦁ Abuse/misuse/diversion: Anabolic steroids may be abused; abuse may be associated with adverse physical and psychological effects.

Geriatric considerations with Deposteron 250

Elderly males treated with androgens may be at increased risk of developing prostatic hyperplasia and prostatic carcinoma. Increase in libido may occur.

Pregnancy risk factor with Deposteron use

X (Contraindicated)

Category X: Studies in animals or human beings have demonstrated fetal abnormalities, or there is evidence of fetal risk based on human experience, or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.

Pregnancy considerations with Deposteron use

Testosterone may cause adverse effects, including masculinization of the female fetus, if used during pregnancy.

Lactation

Enters breast milk – contraindicated in lactation

Breast-Feeding Considerations

Elevated levels of endogenous maternal testosterone, as seen in cases involving certain ovarian cysts, can inhibit milk production. Furthermore, maternal serum testosterone levels generally decrease after pregnancy and return to normal once the mother discontinues breastfeeding. However, the exact quantity of testosterone in breast milk and its impact on the nursing infant following maternal supplementation remain unknown. Consequently, some products should be avoided during breastfeeding due to contraindications

Deposteron Adverse Reactions 

Frequency not always defined.

Cardiovascular

Hypertension (≥3%), increased blood pressure (1%), decreased blood pressure, deep vein thrombosis, edema, vasodilatation.

Central Nervous System

Headache (1% to ≥3%), fatigue (2%), irritability (2%), insomnia (≤2%), mood swings (≤2%), aggressive behavior (1%), taste disorder (1%), altered sense of smell (≤1%), abnormal dreams, amnesia, anxiety, chills, depression, dizziness, emotional lability, excitement, hostility, malaise, nervousness, outbursts of anger, paresthesia, seizure, sleep apnea, suicidal ideation.

Dermatologic

Acne vulgaris (5%), hyperhidrosis (1%), alopecia, contact dermatitis, diaphoresis, erythema, folliculitis, hair discoloration, pruritus, seborrhea, skin rash, xeroderma.

Endocrine & Metabolic

Increased plasma estradiol concentration (3%), weight gain (1%), gynecomastia (≤1%), hot flash (≤1%), change in libido, decreased gonadotropin, fluid retention, hirsutism (increase in pubic hair growth), hypercalcemia, hyperchloremia, hypercholesterolemia, hyperglycemia, hyperkalemia, hyperlipidemia, hypernatremia, hypoglycemia, hypokalemia, inorganic phosphate retention, menstrual disease (including amenorrhea).

Gastrointestinal
Diarrhea (≥3%), gastroesophageal reflux disease, gastrointestinal hemorrhage, gastrointestinal irritation, increased appetite, nausea, vomiting.

Genitourinary

Prostate-specific antigen increase (5% to 11%), prostatitis (≥3%), ejaculatory disorder (1%), prostate induration (1%), spontaneous erections (≤1%), benign prostatic hypertrophy, difficulty in micturition, hematuria, impotence, irritable bladder, mastalgia, oligospermia, priapism, testicular atrophy, urinary tract infection, virilization.

Hepatic

Abnormal hepatic function tests, cholestatic hepatitis, cholestatic jaundice, hepatic insufficiency, hepatic necrosis, hepatocellular neoplasms, increased serum bilirubin, peliosis hepatis.

Hematologic & Oncologic

Increased hematocrit (1% to 3%), increased hemoglobin (2%), malignant neoplasm of the prostate (1%), anemia, clotting factors suppression, hemorrhage, leukopenia, polycythemia, prostate carcinoma.

Hypersensitivity

Anaphylactoid reaction, hypersensitivity reaction (including pulmonary oil microembolism).

Local

Pain at injection site (5%), erythema at injection site (1%), application site reaction (gel, solution), inflammation at the injection site.

Neuromuscular & Skeletal

Arthralgia (≥3%), back pain (≥3%), abnormal bone growth (accelerated), hemarthrosis, hyperkinesia, weakness.

Ophthalmic

Increased lacrimation.

Renal

Increased serum creatinine, polyuria.

Respiratory

Bronchitis (≥3%), nasopharyngitis (≥3%), sinusitis (≥3%), upper respiratory tract infection (≥3%), dyspnea.

<1%, postmarketing, and/or case reports:

• Abdominal pain
• Abnormal erythropoiesis
• Abscess at the injection site
• Allergic dermatitis
• Anaphylactic shock
• Anaphylaxis
• Androgenetic alopecia
• Angina pectoris
• Angioedema
• Asthma
• Breast induration
• Cardiac arrest
• Cardiac failure
• Cerebral infarction
• Cerebrovascular accident
• Cerebrovascular insufficiency
• Chest pain
• Chronic obstructive pulmonary disease
• Circulatory shock
• Cognitive dysfunction
• Confusion
• Coronary artery disease
• Coronary occlusion
• Cough
• Decreased plasma testosterone
• Decreased thyroxine binding globulin
• Decreased urinary calcium excretion
• Diabetes mellitus
• Dysuria
• Electrolyte disturbance
• Epididymitis
• Erectile dysfunction
• Hearing loss (sudden)
• Hematoma at injection site
• Hepatotoxicity (idiosyncratic) (Chalasani, 2014)
• Hyperparathyroidism
• Hypersensitivity angiitis
• Hypertriglyceridemia
• Hyperventilation
• Impaired glucose tolerance
• Increased gamma-glutamyl transferase
• Increased intraocular pressure
• Increased serum ALT
• Increased serum AST
• Increased serum prolactin
• Increased serum transaminases
• Increased serum triglycerides
• Korsakoff’s psychosis (nonalcoholic)
• Migraine
• Musculoskeletal chest pain
• Musculoskeletal pain
• Myalgia
• Myocardial infarction
• Nephrolithiasis
• Nipple tenderness
• Orgasm disturbance (male)
• Osteopenia
• Osteoporosis
• Peripheral edema
• Personality disorder
• Pharyngeal edema
• Pharyngolaryngeal pain
• Prolonged partial thromboplastin time
• Prolonged prothrombin time
• Prostatic intraepithelial neoplasia
• Pulmonary embolism
• Pure red cell aplasia
• Renal colic
• Renal pain
• Respiratory distress
• Restlessness
• Reversible ischemic neurological deficit
• Rhinitis
• Sleep disorder
• Snoring
• Spermatocele
• Syncope
• Systemic lupus erythematosus
• Tachycardia
• Testicular pain
• Thrombocytopenia
• Thromboembolism
• Thrombosis
• Tinnitus
• Transient ischemic attacks
• Urinary incontinence
• Urolithiasis
• Urticaria
• Venous insufficiency
• Venous thromboembolism
• Vesicobullous rash
• Virilization (of children, following secondary exposure to topical gel [advanced bone age, aggressive behavior, enlargement of clitoris requiring surgery, enlargement of penis, increased erections, increased libido, pubic hair development])
• Vitreous detachment
• Voice disorder

Metabolism/Transport effects

Drug Interactions from Deposteron 250

Blood Glucose Lowering Agents: Androgens may enhance the hypoglycemic effect of Blood Glucose Lowering Agents. Risk C: Monitor therapy.

C1 inhibitors: Androgens may enhance the thrombogenic effect of C1 inhibitors. Risk C: Monitor therapy.

Corticosteroids (Systemic): May enhance the fluid-retaining effect of Androgens. Risk C: Monitor therapy.

CycloSPORINE (Systemic): Androgens may enhance the hepatotoxic effect of Cyclosporine (Systemic). Androgens may increase the serum concentration of Cyclosporine (Systemic). Risk D: Consider therapy modification.

Dehydroepiandrosterone: May enhance the adverse/toxic effect of Testosterone. Risk X: Avoid combination.

Vitamin K Antagonists (eg, warfarin): Androgens may enhance the anticoagulant effect of Vitamin K Antagonists. Risk D: Consider therapy modification.

Test interactions with Deposteron

Testosterone may decrease thyroxine-binding globulin, resulting in decreased total T4; free thyroid hormone levels are not changed.

Monitoring parameters with Deposteron use

Periodic liver function tests, lipid panel, hemoglobin and hematocrit (prior to therapy, at 3 to 6 months, then annually); radiologic examination of wrist and hand every 6 months (when using in prepubertal children). Withhold initial treatment with hematocrit >50% (discontinue therapy if hematocrit exceeds 54% [Bhasin, 2010]), hyperviscosity, untreated obstructive sleep apnea, or uncontrolled severe heart failure. Monitor urine and serum calcium and signs of virilization in women treated for breast cancer. Serum glucose (may be decreased by testosterone, monitor patients with diabetes). Evaluate males for response to treatment and adverse events 3 to 6 months after initiation and then annually.

Bone mineral density

Monitor after 1 to 2 years of therapy in hypogonadal men with osteoporosis or low trauma fracture (Bhasin, 2010).

PSA

In men >40 years of age with baseline PSA >0.6 ng/mL, PSA and prostate exam (prior to therapy, at 3 to 6 months, then as based on current guidelines). Withhold treatment pending urological evaluation in patients with palpable prostate nodule or induration or PSA >4 ng/mL or if PSA >3 ng/mL in men at high risk of prostate cancer (Bhasin, 2010).

Do not treat with severe untreated BPH with IPSS symptom score >19.

Serum testosterone: After initial dose titration (if applicable), monitor 3 to 6 months after initiating treatment, then annually.

Deposteron Injection:

Testosterone enanthate or cypionate: Measure midway between injections. Adjust dose or frequency if testosterone concentration is <400 ng/dL or >700 ng/dL (Bhasin, 2010).

Testosterone undecanoate: Measure just prior to each subsequent injection and adjust the dosing interval to maintain serum testosterone in mid-normal range (Bhasin, 2010).

Reference range

Total testosterone, males:

12 to 13 years: <800 ng/dL.
14 years: <1200 ng/dL.
15 to 16 years: 100 to 1200 ng/dL.
17 to 18 years: 300 to 1200 ng/dL.
19 to 40 years: 300 to 950 ng/dL.
>40 years: 240 to 950 ng/dL.

Free testosterone, males: 9 to 30 ng/dL.

Deposteron Dosage forms

Solution, Intramuscular, as cypionate:

Depo-Testosterone: 100 mg/mL (10 mL); 200 mg/mL (1 mL, 10 mL) [contains benzyl alcohol, benzyl benzoate].

Generic: 100 mg/mL (10 mL); 200 mg/mL (1 mL, 10 mL).

Anatomic Therapeutic Chemical (ATC) Classification.

⦁ G03BA03.

Mechanism of action from Deposteron 250

Principal endogenous androgen responsible for promoting the growth and development of the male sex organs and maintaining secondary sex characteristics in androgen-deficient males.

Pharmacodynamics/Kinetics

Duration (route and ester dependent): IM: Cypionate and enanthate esters have longest duration, ≤2 to 4 weeks; Undecanoate 10 weeks; Gel: 24 to 48 hours; buccal system: 2 to 4 hours after removal.

Protein binding: 98%; bound to sex hormone-binding globulin (40%) and albumin.

Metabolism: Hepatic; forms metabolites, including dihydrotestosterone (DHT) and estradiol (both active).

Half-life elimination: Variable: 10 to 100 minutes.

Excretion: Urine (90%); feces (6%).

Effects on bleeding

No information available to require special precautions.

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