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Nandrolone Decanoate 250mg 10amp – Medical Tech USA Steroids


Nandrolone has a low tendency for estrogen conversion, estimated to be only about 200% of that seen with testosterone. This is because while the liver can convert nandrolone to estradiol, in other more active sites of steroid aromatization such as adipose tissue nandrolone is far less open to this process. Elevated estrogen levels may still be noticed with higher dosing, however, and may cause side effects such as increased water retention, body fat gain, and gynecomastia.

Introduction to Nandrolone Decanoate

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Nandrolone decanoate
 is an anabolic steroid medication and derivative of the hormone testosterone. It is known by the brand names Deca-Durabolin, Deca-Durabol, and others. Nandrolone decanoate is one of the most widely used anabolic steroids in the world.

Nandrolone decanoate is classified as an androgen and anabolic steroid (AAS). It acts as an agonist of the androgen receptor (AR), the biological target of androgens like testosterone. This gives it pronounced effects on muscle growth and physical performance.

What are Anabolic Androgenic Steroids?

what are androgens

The Anabolic steroids are synthetic derivatives of the naturally occurring male sex hormone testosterone. They possess both muscle-building anabolic properties and masculinizing androgenic effects.

Anabolic Effects

The anabolic effects of Anabolic Androgenic Steroid like testosterone stimulate protein synthesis and muscle growth. When taken exogenously, Anabolic Androgenic Steroid bind to androgen receptors in muscle cells, activating processes that significantly increase protein production to build lean tissue.

At supraphysiological doses, Anabolic Androgenic Steroids augment lean muscle mass, strength, and physical performance far beyond natural limits. This allows for dramatic muscle growth exceeding genetic boundaries.

Androgenic Effects

In addition to anabolic properties, Anabolic Androgenic Steroid also exert androgenic effects associated with male sexual characteristics:

  • Development of primary and secondary sex organs
  • Deepened voice during puberty
  • Increased growth of body and facial hair
  • Enhanced libido and reproductive function

An androgen receptor agonist is a compound that stimulates the androgen receptors in the body, typically mimicking the effects of naturally occurring androgens like testosterone. These agonists have diverse medical applications, including the treatment of conditions such as prostate cancer and certain types of breast cancer, where reducing the effects of androgens is beneficial. By binding to and activating the androgen receptors, these agonists can modulate various physiological processes, influencing aspects like muscle growth, bone density, and sexual characteristics.

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Ratio of Effects Varies Between Anabolic Androgenic Steroids

The specific ratio of anabolic to androgenic effects differs between various AAS compounds depending on their precise molecular structure. Certain synthetic steroids have been engineered to retain powerful anabolic benefits with less androgenic activity. Effective anabolic steroids control is essential for both the well-being of athletes and the integrity of sports.

Potential Health Risks

Irresponsible abuse of AAS have side effects incluide hormone balance, cardiovascular health, mood, liver function, and more. But under medical supervision, AAS can safely help men with clinically low testosterone restore normal levels.

Mechanism of Action from Nandrolone Decanoate

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Nandrolone decanoate is a prodrug of nandrolone in the body. As an AAS, it has:

  • Anabolic effects like stimulation of muscle growth
  • Androgenic effects like development of male sex characteristics
  • Some estrogenic activity
  • Progestogenic activity

The anabolic effects of nandrolone decanoate promote:

  • Protein synthesis
  • Muscle growth
  • Increased bone mineral density
  • Appetite stimulation
  • Increased red blood cell production

This leads to increased muscle mass and improved physical performance.

Medical Uses

Nandrolone decanoate is approved for medical use in some countries for:

  • Treating anemia
  • Counteracting catabolic states like HIV/AIDS wasting syndrome
  • Improving osteoporosis in postmenopausal women
  • Adjunctive therapy for breast cancer

It has historically been prescribed for many other conditions but use has become more restricted over time.

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Exploring the Medical Uses and Benefits of Nandrolone Decanoate in the USA

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Although Nandrolone steroid has becoming more restricted in USA, nandrolone decanoate still has approved medical uses in some countries.   Medical uses with nandrolone decanoate have been well studied in conditions with anemia, osteoporosis, and other diseases.

Approved Indications

Nandrolone decanoate is specifically approved for:

  • Treating anemia associated with chronic kidney disease
  • Increasing bone mineral density and preventing osteoporosis in postmenopausal women
  • Palliative treatment of inoperable breast cancer

It may also be used off-label to treat:

  • HIV/AIDS wasting syndrome
  • Other catabolic states characterized by loss of lean muscle mass

Mechanism of Action

The anabolic effects of nandrolone decanoate can help:

  • Increase production of red blood cells to treat anemia
  • Build and preserve lean muscle mass
  • Increase bone density and strength
  • Stimulate appetite

By preventing loss of lean mass, it can help counteract catabolic states.

The mediocre androgenic effects may also inhibit breast cancer progression.


Typical dosages of nandrolone decanoate:

  • Anemia (adults): 50-100 mg every 2-4 weeks
  • Anemia (children): 25-50 mg every 3-4 weeks
  • Osteoporosis: 50 mg every 2-4 weeks
  • Breast cancer: 50 mg every 2-4 weeks

Doses for HIV/AIDS wasting can range from 100-400 mg every 2-4 weeks.

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Some benefits of nandrolone can cause:

  • High anabolic to androgenic ratio
  • Long-lasting depot formulation
  • Well-tolerated compared to other AAS
  • Lower abuse potential than other AAS

This makes it suitable for female patients and children.


Disadvantages of nandrolone can cause:

  • Virilization side effects in women
  • Suppression of natural testosterone production
  • Some risk of liver toxicity
  • Requires deep intramuscular injection

Use requires close medical supervision and monitoring for side effects. Availability is becoming limited.

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Understanding the Side Effects of Nandrolone Steroid in the USA

Although generally well-tolerated, nandrolone steroid can cause various side effects. These are more likely at higher doses or with extended treatment. Nandrolone steroid is one of the most commun used in USA by american people, is really important to understand

The most Common Side Effects Nandrolone

Nandrolone can cause some common side effects include:

  • Headaches
  • Acne
  • Nausea
  • Changes in libido
  • Suppression of natural testosterone
  • Edema (water retention)
  • Blood filled cysts

These tend to be mild at typical medical dosages.

Endocrine Effects

Nandrolone can cause anormal hormonal function:

  • Suppression of testosterone production resulting in testicular atrophy and impaired sperm production in males
  • Virilization – development of male sex characteristics in women
  • Gynecomastia – breast tissue growth in men
  • Hormonal imbalances including reduced LH, FSH, estrogen, and progesterone levels
  • Dyslipidemia – changes in cholesterol and lipid levels

These effects are related to interference with the hypothalamic-pituitary-gonadal axis that regulates sex hormones.

Many endocrine effects reverse after treatment stops, but some may be permanent even after short-term use.


There is a risk of liver issues including:

  • Elevated liver enzymes
  • Cholestatic jaundice
  • Peliosis hepatis
  • Benign and malignant liver tumors

However, nandrolone decanoate is not as hepatotoxic as some other AAS that are C17-alpha alkylated.

Cardiovascular Effects

Some cardiovascular side effects may include:

  • Increased hematocrit and blood viscosity
  • Alterations in blood lipids
  • Hypertension
  • Functional changes in the heart muscle
  • Increased risk of blood clots

These could increase the risk of events like stroke or heart attack, especially in those predisposed.

Careful medical monitoring is essential to minimize risks and catch any serious side effects early on. Those with pre-existing health conditions may not be good candidates.

American Nandrolone Steroid Usage in Bodybuilding

Although a controlled substance in many countries, nandrolone decanoate is commonly used illicitly by athletes and bodybuilders for its muscle-building effects.

Popularity in Sports from Nandrolone Steroid in USA

Nandrolone decanoate is one of the most widely abused anabolic steroids worldwide. Reasons for its popularity include:

  • High anabolic, muscle-building potential
  • Low androgenic or masculinizing side effects
  • Long-lasting depot formulation for convenient dosing
  • Low rate of estrogenic side effects like gynecomastia

It became popular among bodybuilders and athletes in the 1960s and 1970s.

Advantages for Muscle Growth

Key reasons nandrolone decanoate boosts muscle mass:

  • Increases nitrogen retention and protein synthesis
  • Promotes skeletal muscle hypertrophy
  • Stimulates appetite and allows increased calorie intake
  • Enhances recovery between workouts
  • Increases red blood cell production for better muscular endurance

Nandrolone is especially effective when it is combined with strength training and a high-protein diet. Additionally, its benefits become even more pronounced when used in conjunction with these practices.


Bodybuilders may take 200-600 mg per week, sometimes stacked with other steroids:

  • Beginners: 200-400 mg/week
  • Intermediate: 400-600 mg/week
  • Advanced: 600-800 mg/week

Cycles typically last 8-12 weeks. Higher doses increase the risks of side effects.

Athletes tend to use lower doses like 100-200 mg/week.

Some take nandrolone decanoate continuously for years to maintain muscle size. This is not recommended due to health risks.

Side Effects in Men

Possible side effects for men include:

  • Testicular atrophy
  • Reduced sperm count and motility
  • Erectile dysfunction
  • Breast tissue growth (gynecomastia)
  • Fluid retention
  • Acne and oily skin
  • Hair loss
  • Increased aggression (“roid rage”)

Heart disease and liver toxicity are also risks with heavy use.

Side Effects in Women

In women, nandrolone decanoate causes virilization:

  • Deepened voice
  • Facial and body hair growth
  • Male pattern baldness
  • Enlarged clitoris
  • Irregular periods
  • Increased libido

Some changes like voice deepening may be permanent.

Illegally obtaining and using nandrolone decanoate or any other AAS can lead to legal consequences. A physician should monitor anyone using it for medical purposes.

Nandrolone  decanoate is classified as a controlled substance in many countries. This makes non-medical use illegal.

United States

Nandrolone steroid  is categorized as a Schedule III controlled substance  in USA under the Controlled Substances Act.

It is illegal to possess or use nandrolone decanoate without a valid medical prescription. Doing so can result in fines or imprisonment.

Illicit trafficking also carries strict penalties. Nandrolone decanoate was added to the controlled substances list in 1991.

United Kingdom

Nandrolone decanoate is a Class C substance under the Misuse of Drugs Act.

While less strictly controlled than substances in Classes A and B, possession and supply without a prescription from a medical practitioner is still illegal.


Canada’s Controlled Drugs and Substances Act classifies nandrolone decanoate in Schedule IV.

It is illegal for Canadians to possess, seek, obtain, import, export, or transport nandrolone decanoate without a prescription.


In Australia, nandrolone decanoate is categorized as a Schedule 4 (S4) prescription-only substance under the Standard for Uniform Scheduling of Medicines and Poisons.

Global Restrictions

The International Olympic Committee and many other sports organizations prohibit nandrolone decanoate and other anabolic steroids.

However, illicit use continues among high-level athletes. Improved testing is making this more difficult.

Medical use is still allowed in some countries under a physician’s supervision. But availability of nandrolone decanoate is becoming more limited worldwide.

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Research Studies on Nandrolone Decanoate

Although approved medical uses are becoming restricted, research continues on the effects and toxicity of nandrolone decanoate.

Effects on Muscle Growth

Many studies confirm the ability of nandrolone decanoate to boost muscle growth:

  • A 12-week study in 32 men found that 600 mg/week of nandrolone decanoate significantly increased lean muscle mass and strength.
  • Multiple studies show nandrolone decanoate stimulates skeletal muscle hypertrophy and strength when combined with strength training.
  • Research shows it stimulates protein synthesis and nitrogen retention more than testosterone.

This supports its efficacy for increasing muscle mass and athletic performance.

Impact on Bone Mineral Density

Several studies assessed effects on bone:

  • A 20-week study in rabbits found nandrolone decanoate improved bone mineral density at a dosage of 1 mg/kg.
  • However, short 6-8 week studies in men found no significant impact on bone density.

Further research is needed on its long-term effects on bone health.

Side Effects and Toxicity

Many studies focused on safety and side effects:

  • Animal studies show nandrolone decanoate disrupts fertility and reproduction at doses over 1 mg/kg.
  • At a dose of 1.5 mg/kg in rats, nandrolone decanoate increased heart weights by 20% after just 2 weeks.
  • Studies confirm increased hematocrit, LDL cholesterol levels, and reduced HDL cholesterol.
  • High doses reduced immune system markers in animal studies.

Anti-Catabolic Uses

Some studies focused on medical uses:

  • Nandrolone decanoate at 100 mg biweekly reduced muscle loss in men with HIV wasting syndrome.
  • Doses of 50-100 mg every 3-4 weeks raised hemoglobin levels in kidney disease patients with anemia.
  • A dose of 50 mg every 3 weeks increased bone density in postmenopausal women with osteoporosis.

This supports use for treating catabolic states and osteoporosis.

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Mechanisms of Action

Molecular mechanisms have been extensively studied:

Mechanism Effect
AR agonist Muscle growth, androgenic effects
5α-reductase interaction Reduced androgenic activity
Estrogenic activity Fluid retention, breast tissue growth
Progestogenic activity Suppresses gonadotropins
Antigonadotropic effects Hypothalamic-pituitary-gonadal axis suppression
Interference with liver enzymes Disruption of cholesterol and lipid metabolism

Detection in Body Fluids

Sensitive assays can detect nandrolone use:

  • GC/MS or LC/MS/MS can detect nandrolone metabolites in urine for months after cessation.
  • Hair analysis by LC/MS/MS can detect chronic use up to 1 year.

These tests help deter abuse by athletes. But false positives are an issue.

Future Research Directions

Further research could:

  • Better define long-term impacts on fertility, cardiovascular health, lipids, liver function, and more.
  • Refine urine, blood, and hair testing methods to avoid false positives.
  • Investigate modified analogs and formulations to improve therapeutic index.
  • Explore topical formulations to avoid deep injection.
  • Assess efficacy and safety for additional medical uses.

Carefully controlled research helps maximize the medical benefits of nandrolone decanoate while minimizing the associated risks.

What are Nandrolone Esters?

Nandrolone is a synthetic anabolic-androgenic steroid that has gained popularity for its muscle-building and performance-enhancing effects. Like other injectable steroids, nandrolone is administered in an esterified form for prolonged release and activity in the body.

Overview of Nandrolone Esters

Nandrolone esters refer to nandrolone that has been modified with an ester chain attached at the 17-beta hydroxyl group. This esterification makes the nandrolone molecule more lipophilic or fat-soluble.

The ester chains control the release rate and extend the half-life of nandrolone in the body. Once administered by intramuscular injection, enzymes slowly cleave off the ester chain, releasing active nandrolone gradually over time.

Common Nandrolone Esters are

The most widely used esterified forms of nandrolone are:

  • Nandrolone decanoate – Most popular ester with a half-life of 6-8 days. Brand name Deca Durabolin.
  • Nandrolone phenylpropionate – Shorter 2-3 day half-life. Less common than decanoate.
  • Nandrolone laurate – Intermediate ester with a 4-5 day half-life.
  • Nandrolone cypionate – Long-acting ester like decanoate. Half-life of 8 days.
  • Nandrolone undecylate – Very long 11-12 day half-life. Extended-release durability.

Nandrolone decanoate (Deca) remains the most frequently used and researched clinical and performance-enhancing nandrolone ester.

Benefits of Esterification

The added ester provides key advantages:

  • Requires less frequent dosing. Only 1-2 injections per week needed for most nandrolone esters.
  • Makes injections less painful by dispersing active steroid into oil solution.
  • Provides steady release and stable blood levels over time. Less peaks and valleys.
  • Extends the detection time window making drug testing evasion easier.

However, some individuals may react to particular ester components that can cause site irritation or allergies in rare cases.

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Usage Considerations

While valued for boosting muscle growth and strength, nandrolone esters carry common steroid side effects. They can suppress natural testosterone production and potentially impact cardiovascular health markers when abused chronically.

Anyone using nandrolone should follow proper post cycle therapy protocols after use. Those with heart, liver, or kidney conditions require medical guidance to minimize health risks and balance potential benefits.

In summary, esterification modifies nandrolone’s release rate for convenient dosing schedules and steady blood levels. But as with all anabolic steroids, responsible use practices remain imperative.


In the world of anabolic androgenic steroids (AAS), it’s crucial to understand the potential side effects, both when you start and when you stop using them. These substances, while sometimes used for the treatment of various medical conditions, have also been associated with serious health risks. The fact that AAS are considered a controlled substance under the Anabolic Steroids Control Act highlights the need for caution. It’s essential to be aware that some side effects, including high blood pressure, nausea, and vomiting, can be quite severe.

Studies have shown that AAS, such as nandrolone decanoate, can have both strong anabolic effects, contributing to increased muscle mass and strength, and weak androgenic effects. While the anabolic effect has been utilized for medical purposes, inoperable breast cancer being one example, these substances also come with risks. Chronic kidney failure and low-density lipoprotein levels have been reported in connection with AAS use and abuse.

Many sports organizations worldwide, including the World Anti-Doping Agency and the United Kingdom Anti-Doping Agency, have strict regulations against the use, abuse, and side effects of AAS. Athletes need to be aware of the consequences, as studies suggest that nandrolone can affect the endocrine system and lead to negative nitrogen balance.

In conclusion, while AAS may offer benefits in certain medical situations, they carry potential risks that athletes and individuals should consider carefully. Responsible use, under the guidance of medical professionals, is essential to minimize side effects and ensure overall health. Always seek medical advice, diagnosis, and treatment options, and remember that the use of AAS should be approached with caution and in full compliance with the law. All rights reserved.

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