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Nandrolone Phenylpropionate Human Pharma Durabolin

Original price was: $99.00.Current price is: $95.00.

Durabolin Nandrolone Phenylpropionate 100mg/10ml by Human Pharma
Durabolin, featuring Nandrolone Phenylpropionate (NPP), is a fast-acting anabolic steroid designed for muscle growth, strength enhancement, and recovery. This product comes in a 10ml ampoule with a concentration of 100mg/ml, making it ideal for precision dosing.

Known for its shorter half-life compared to other nandrolone esters, NPP provides rapid results, making it a popular choice for both bulking and cutting cycles. It supports lean muscle mass development, reduces joint pain through increased collagen synthesis, and aids in faster recovery after intense workouts.

Nandrolone Phenylpropionate Human Pharma Durabolin is an anabolic steroid used in various medical treatments. It was developed in the 1950s and is known for its potent anabolic properties. The compound is often administered through intramuscular injection and has applications in treating conditions like breast cancer, osteoporosis, and anemia. Its non-medical use, particularly in sports and bodybuilding, raises important legal and health concerns.

History and Development of Nandrolone Phenylpropionate Human Pharma

The history and development of Nandrolone Phenylpropionate trace back several decades, highlighting its significance in both medical and athletic fields. This compound has evolved significantly since its inception, reflecting advancements in pharmaceutical science and changing therapeutic needs.

Nandrolone Phenylpropionate Origins and Discovery

Nandrolone was first discovered in the 1950s when researchers sought to develop new anabolic agents. It is derived from testosterone and was initially synthesized by chemists looking to create a substance that could retain the muscle-building properties of testosterone while minimizing its androgenic effects. In 1957, Nandrolone Phenylpropionate was introduced to the medical field as one of the earliest anabolic steroids. Its unique properties allowed it to stand out among its peers.

Evolution in Medical Use

Over the years, the uses of Nandrolone Phenylpropionate have expanded significantly. Initially, it gained attention for its application in hormone replacement therapies and treatment of various medical conditions. Specifically, it proved useful in:

  • Treating severe weight loss due to chronic illnesses
  • Supporting muscle development in patients undergoing severe physical stress
  • Assisting in recovery post-surgery or injury

In the 1960s and 1970s, the steroid became well-established in the management of conditions like breast cancer and osteoporosis. This period marked the beginning of its acceptance within medical protocols, particularly in enhancing the quality of life for individuals suffering from debilitating diseases. Medical professionals recognized its potential to stimulate appetite and facilitate muscle growth, thereby improving overall patient outcomes.

Throughout the 1980s and into the 1990s, Nandrolone Phenylpropionate continued to be utilized within controlled therapeutic settings, although it faced increased scrutiny due to emerging concerns regarding anabolic steroid abuse in sports. Despite these challenges, its efficacy in legitimate medical applications helped maintain its status as a vital therapeutic agent in select cases. Recognized for its lower androgenic activity, it became favored for use in female patients and children, where minimizing androgenic side effects was particularly crucial.

The chemical composition and formulation of nandrolone phenylpropionate play a crucial role in its pharmacological properties and effectiveness as a therapeutic agent. Understanding its structural characteristics and formulation provides insight into its usage in clinical settings.

Chemical Composition and Formulation

Human Pharma Durabolin Nandrolone Phenylpropionate
Human Pharma Durabolin Nandrolone Phenylpropionate

Structural Characteristics

Nandrolone phenylpropionate is an anabolic steroid derived from testosterone, modified to enhance its anabolic properties while minimizing androgenic effects. The chemical structure consists of a 19-nortestosterone backbone, with a phenylpropionate ester attached to the 17β position. This structural modification allows it to have a longer half-life and a more gradual release into the bloodstream.

The molecular formula of nandrolone phenylpropionate is C27H34O3, indicating it comprises 27 carbon atoms, 34 hydrogen atoms, and 3 oxygen atoms. This composition contributes to its stability and solubility in oil-based solutions, making it suitable for intramuscular injections.

Formulation for Intramuscular Injection

Nandrolone phenylpropionate is typically available in oil-based injectable formulations, which facilitate efficient administration and absorption. Common concentrations include 25 mg/mL and 50 mg/mL, depending on the specific product and its intended use.

Injections are usually administered intramuscularly, targeting areas such as the gluteus or thigh muscles. This route of administration allows for a gradual release of the active compound into the bloodstream, resulting in sustained therapeutic effects. The formulation may also include various additives to enhance stability and reduce potential pain or irritation at the injection site.

  • Common formulations may contain:
    • Benzyl Alcohol: Acts as a preservative.
    • Castor Oil: Serves as a solvent to enhance solubility.
    • Sesame Oil: Often used as a carrier oil.

Since the formulation is crucial to its pharmacokinetics, ensuring adequate quality control during production is vital for safety and effectiveness. Proper storage and handling conditions also contribute to maintaining the integrity of the product prior to use.

Nandrolone Phenylpropionate Human Pharma Pharmacological Properties

The pharmacological properties of Nandrolone Phenylpropionate play a crucial role in its medical applications and understanding of its effects on the body. These properties encompass its mechanism of action, pharmacodynamics, and pharmacokinetics.

Mechanism of Action

Nandrolone Phenylpropionate exhibits its effects primarily through its interaction with androgen receptors. It binds to these receptors, mimicking the action of natural testosterone, leading to various anabolic processes in the body.

Interaction with Androgen Receptors

The binding of Nandrolone to androgen receptors triggers a cascade of biological activities that promote protein synthesis, increase muscle mass, and enhance red blood cell production. This interaction is pivotal for understanding both its therapeutic uses and its potential for abuse.

Anabolic Steroid Properties

As an anabolic steroid, Nandrolone Phenylpropionate is characterized by its ability to build muscle and enhance recovery. It possesses a unique profile that focuses more on anabolic effects while exhibiting lower androgenic activity compared to testosterone. This makes it particularly appealing for specific patient groups.

Pharmacodynamics and Pharmacokinetics

The pharmacodynamics and pharmacokinetics of Nandrolone Phenylpropionate further illustrate its efficacy and safety profile. Understanding these factors is essential for determining dosages and predicting outcomes in clinical settings.

Anabolic and Androgenic Effects

  • Superior anabolic effects manifest as improved muscle mass and strength.
  • Lower androgenic effects reduce the risk of virilization in women.

This balance of effects contributes to its acceptance in both medical and athletic circles, despite the controversies surrounding steroid use.

Metabolism and Half-Life

Nandrolone Phenylpropionate has a relatively extended half-life, approximately one week. After administration, it is metabolized in the liver, converting to its active form, nandrolone. This extended half-life allows for less frequent dosing, which can be advantageous in a therapeutic context.

This pharmacokinetic profile is vital for healthcare providers in managing therapy regimens, ensuring effective treatment while minimizing potential risks. The slower release into the bloodstream supports sustained anabolic effects, making it a reliable option for muscle recovery and growth.

Nandrolone Phenylpropionate Human Pharma Approved Medical Uses

The medical applications of Nandrolone Phenylpropionate have been recognized for various therapeutic conditions. Its efficacy in promoting recovery and enhancing health outcomes makes it a valuable compound in specific medical scenarios.

Treatment of Breast Cancer

Nandrolone Phenylpropionate has found a niche in the treatment of breast cancer, particularly in post-menopausal women. When used as part of a comprehensive treatment plan, it may help to improve the quality of life by supporting weight maintenance and muscle strength during chemotherapy. The anabolic properties of this steroid can assist in counteracting the muscle wasting often associated with cancer therapies.

Osteoporosis Management

This compound is beneficial in managing osteoporosis, especially in women who are post-menopausal. Osteoporosis leads to a decrease in bone density, making fractures more likely. Nandrolone Phenylpropionate has demonstrated its ability to enhance bone mineral density effectively. Its administration can reduce the risk of fractures in vulnerable populations by stimulating bone formation and inhibiting bone resorption.

Use in Anemia Treatment

Nandrolone Phenylpropionate is also utilized in the treatment of anemia, particularly in patients with chronic renal failure. The steroid can stimulate erythropoiesis, or red blood cell production, thus aiding in alleviating anemia symptoms. By enhancing the production of red blood cells, patients may experience improved energy levels and better overall health outcomes.

Dosage Guidelines for Nandrolone Phenylpropionate Human Pharma in Bodybuilding

Nandrolone Phenylpropionate (NPP) is a popular anabolic steroid among bodybuilders due to its short half-life, rapid action, and versatility in both bulking and cutting cycles. Proper dosage and cycle planning are essential to optimize its benefits while minimizing risks. Below is a detailed guide to help users understand how to incorporate NPP into their routines effectively.

Recommended Dosages for Different Experience Levels

  • For Beginners:
    A starting dose of 100-200 mg per week is ideal for first-time users. This allows them to assess their body’s response to NPP while keeping potential side effects manageable.
  • For Intermediate Users:
    A dosage range of 200-400 mg per week is commonly used. This provides significant anabolic effects, including enhanced muscle growth and recovery.
  • For Advanced Users:
    Experienced individuals often use 400-600 mg per week, aiming for maximum gains in size and strength. However, this level requires careful monitoring to avoid adverse effects.

Cycle Duration and Administration Frequency

Due to its short half-life of approximately 2-4 days, NPP requires frequent injections, typically every other day (EOD), to maintain stable blood levels. Standard cycle lengths range from 6 to 8 weeks, making it ideal for users seeking faster results without prolonged exposure.

Sample NPP Steroid Cycles

  1. Beginner Cycle:
    • Duration: 6-8 weeks
    • NPP: 100-200 mg/week
    • Testosterone Propionate: 200-300 mg/week (to prevent hormonal imbalance)
    • Post-Cycle Therapy (PCT): Begin during weeks 6-8 with Clomiphene Citrate or Tamoxifen.
  2. Intermediate Cycle:
    • Duration: 8-10 weeks
    • NPP: 300-400 mg/week
    • Testosterone Enanthate: 400 mg/week
    • Optional: Winstrol (Stanozolol) oral at 50 mg/day during the final 4 weeks for a cutting phase.
  3. Advanced Cycle:
    • Duration: 10 weeks
    • NPP: 400-600 mg/week
    • Testosterone Cypionate: 500 mg/week
    • Optional Kickstart: Dianabol (Methandrostenolone) at 30 mg/day during the first 4 weeks.

Post-Cycle Therapy (PCT) Considerations

After completing a cycle, restoring natural testosterone production is critical to prevent long-term suppression.

  • PCT Example Protocol:
    • Clomiphene Citrate (Clomid): 50 mg/day for 3-4 weeks.
    • Tamoxifen (Nolvadex): 20-40 mg/day for 3-4 weeks.
    • HCG (Human Chorionic Gonadotropin): Optional, used at 1,000 IU every other day for 2 weeks before starting Clomid or Tamoxifen.

Understanding the Half-Life of Nandrolone Phenylpropionate Human Pharma

The half-life of a steroid plays a crucial role in determining its administration frequency, cycle length, and overall effectiveness. Nandrolone Phenylpropionate (NPP) is known for its relatively short half-life compared to other nandrolone esters like decanoate, making it a favorite among bodybuilders for shorter, more controlled cycles.

What is the Half-Life of NPP?

NPP has a half-life of approximately 2 to 4 days, meaning it clears the system faster than long-ester alternatives. This short duration allows users to make quicker adjustments during cycles and is especially beneficial for athletes who need to manage detection times.

Implications of the Short Half-Life

  • Frequent Injections Required:
    To maintain stable blood plasma levels, NPP must be administered every other day (EOD) or three times per week.
  • Shorter Cycles:
    Most NPP cycles are limited to 6-8 weeks, making it an excellent option for users seeking rapid results with reduced long-term exposure.

Comparison with Long-Acting Nandrolone Decanoate

  • NPP: Clears the system faster, allowing for more controlled and flexible cycles.
  • Deca-Durabolin (Nandrolone Decanoate): Features a half-life of 6-12 days, requiring fewer injections but lingering longer in the system, increasing detection risk for athletes.

Practical Applications in Bodybuilding

  • Bulking Cycles: NPP provides rapid muscle growth and strength improvements with lower water retention compared to longer esters.
  • Cutting Cycles: Its fast clearance makes it ideal for the final stages of preparation, especially for competitions or photo shoots.

Monitoring and Adjustments

Regular monitoring of blood work during an NPP cycle is essential to track hormone levels, liver enzymes, and cardiovascular health. Users should always adjust doses or injection frequencies based on individual responses and goals.

By understanding the half-life of Nandrolone Phenylpropionate and its pharmacological implications, bodybuilders can optimize their cycles for maximum benefits while minimizing health risks.

Nandrolone Phenylpropionate Human Pharma Cycles and Combination

Nandrolone Phenylpropionate (NPP) is a versatile anabolic steroid that can be effectively incorporated into a variety of cycles depending on the user’s goals, whether bulking, cutting, or enhancing athletic performance. The shorter half-life of NPP compared to other nandrolone esters allows for more precise control of dosing and a quicker onset of results. Below, we explore common NPP cycles and its combinations with other steroids to maximize benefits while minimizing potential risks.

Why Use NPP in a Cycle?

NPP offers several advantages that make it an excellent choice for both beginners and experienced users:

  • Fast Onset of Action: Its short ester allows for noticeable results within the first few weeks.
  • Reduced Water Retention: Compared to Deca-Durabolin, NPP results in less water retention, making it suitable for lean muscle gains.
  • Versatility: It can be used in both bulking and cutting cycles due to its ability to enhance muscle growth and improve recovery.
  • Short Detection Time: This is beneficial for athletes subject to drug testing.

Common NPP Cycles

  1. Beginner Cycle
    • Duration: 6-8 weeks
    • NPP Dosage: 100-200 mg per week
    • Testosterone Propionate: 200-300 mg per week
    • Purpose: Ideal for those new to steroids, focusing on moderate muscle gains and improved recovery.
    • Notes: Always include a Post-Cycle Therapy (PCT) plan to restore natural testosterone production.
  2. Intermediate Bulking Cycle
    • Duration: 8-10 weeks
    • NPP Dosage: 300-400 mg per week
    • Testosterone Enanthate: 400 mg per week
    • Dianabol (Optional Kickstart): 30 mg/day for the first 4 weeks
    • Purpose: Suitable for users looking to add significant muscle mass and strength.
    • Notes: Incorporate liver support supplements if using Dianabol.
  3. Advanced Cycle for Lean Bulking
    • Duration: 10 weeks
    • NPP Dosage: 400-600 mg per week
    • Testosterone Cypionate: 500 mg per week
    • Anavar (Oxandrolone): 50 mg/day during the last 4 weeks for lean gains and hardness
    • Purpose: Designed for experienced users seeking a combination of size, strength, and lean muscle definition.
  4. Cutting Cycle
    • Duration: 6-8 weeks
    • NPP Dosage: 200-300 mg per week
    • Testosterone Propionate: 300 mg per week
    • Winstrol (Stanozolol): 50 mg/day
    • Purpose: Aimed at reducing body fat while maintaining lean muscle mass and enhancing vascularity.
    • Notes: Ensure hydration to mitigate joint dryness associated with Winstrol.

Combining NPP with Other Steroids

1. Testosterone:
Testosterone is essential in almost all NPP cycles to maintain hormonal balance and prevent issues like low libido or lethargy due to the suppression of natural testosterone production.

  • Preferred Types: Testosterone Propionate for shorter cycles; Testosterone Enanthate or Cypionate for longer ones.
  • Ratio: Maintain a 1:1 or 1:1.5 ratio of testosterone to NPP for optimal synergy.

2. Dianabol (Methandrostenolone):
This oral steroid is often used to kickstart bulking cycles, providing rapid strength and muscle mass gains.

  • Cycle Tip: Limit Dianabol use to the first 4-6 weeks to avoid liver strain.

3. Winstrol (Stanozolol):
Winstrol is commonly combined with NPP in cutting cycles to promote a lean, defined physique.

  • Benefits: Enhances muscle hardness and vascularity while complementing the anabolic effects of NPP.

4. Anavar (Oxandrolone):
Anavar is another mild oral steroid used in both bulking and cutting cycles.

  • Benefits: Promotes lean muscle gains with minimal water retention and supports fat loss.

5. Trenbolone:
For advanced users, combining NPP with Trenbolone can result in unparalleled strength and size gains. However, this combination requires careful management due to the high risk of side effects.

  • Warning: This stack is not recommended for beginners or those without prior experience with both compounds.

Cycle Safety and Monitoring

While combining NPP with other steroids can amplify results, it also increases the likelihood of side effects. To minimize risks:

  • Blood Work: Regularly monitor hormone levels, liver enzymes, and cardiovascular markers.
  • Liver Protection: Use supplements like milk thistle or N-acetyl cysteine (NAC) if incorporating oral steroids.
  • Aromatase Inhibitors (AI): Control estrogen-related side effects like gynecomastia by using an AI (e.g., Arimidex or Letrozole) as needed.
  • PCT Plan: Always include a comprehensive PCT with Clomid, Nolvadex, or HCG to restore natural testosterone production.

By tailoring NPP cycles and combinations to your experience level and goals, you can achieve impressive results while maintaining health and safety. Always consult a knowledgeable medical professional or experienced coach before starting a cycle.

Nandrolone Phenylpropionate Side Effects and Health Risks

The use of anabolic steroids like nandrolone phenylpropionate can lead to various side effects and health risks. Understanding these issues is vital for users to make informed decisions regarding their use and to manage potential complications effectively.

Effects in Men

Men may experience several adverse effects as a result of nandrolone use. These can include:

  • Testicular Atrophy: The hormone can suppress natural testosterone production, leading to shrinkage of the testicles.
  • Decreased Sperm Count: Extended use may result in reduced fertility due to lower sperm production.
  • Gynecomastia: Some men may develop breast tissue, caused by hormonal imbalances and conversion of nandrolone to estrogen.
  • Skin Changes: Oily skin and acne are common side effects, as well as other dermatological issues.
  • Hair Loss: Male pattern baldness can be accelerated by the androgenic effects of the steroid.

Effects in Women

Women using nandrolone phenylpropionate may encounter significant side effects, including:

  • Masculinization: Development of male characteristics such as deepening of the voice, increased body hair, and clitoral enlargement.
  • Menstrual Irregularities: Disruptions in menstrual cycles are common in women using the steroid.
  • Altered Libido: Changes in sexual drive, which can either increase or decrease, depending on the individual.

Cardiovascular and Hepatic Concerns

Nandrolone phenylpropionate is associated with various cardiovascular and liver-related issues:

  • Cardiovascular Disease: Prolonged use can contribute to atherosclerosis, increasing the risk of heart attacks and strokes.
  • Hypertension: Elevated blood pressure can occur, leading to further cardiovascular complications.
  • Liver Damage: While nandrolone is less toxic to the liver than some other steroids, the potential for harm exists, particularly with prolonged usage.
  • Peliosis Hepatica: This rare but serious condition involves the formation of blood-filled cysts in the liver.

Psychological Impact

The psychological effects of using nandrolone can be profound. Users may experience:

  • Aggression and Mood Swings: Increased irritability and aggressive behavior are often reported, commonly referred to as “roid rage.”
  • Depression: Some users may experience significant mood disturbances, leading to depressive symptoms once the steroid use is discontinued.
  • Psychiatric Disorders: Long-term use has been linked to other mental health issues, including anxiety and in severe cases, psychosis.

Nandrolone Phenylpropionate Human Pharma Interactions with Other Drugs

The interactions of Nandrolone Phenylpropionate with other medications can significantly influence its efficacy and safety profile. Understanding these interactions is crucial for optimizing treatment outcomes and minimizing potential risks. Below are the key categories of drug interactions associated with this compound.

Antiestrogenic Drugs

Antiestrogenic medications are often utilized to counteract the estrogenic effects that can arise from testosterone derivatives, including nandrolone. These drugs include:

  • Selective Estrogen Receptor Modulators (SERMs)
  • Aromatase Inhibitors (AIs)

By blocking estrogen activity or preventing estrogen production, antiestrogenic drugs can help mitigate unwanted side effects, such as gynecomastia. Patients using nandrolone may implement these agents to maintain hormonal balance, but the interaction’s specific outcomes can vary based on individual circumstances.

Interaction with 5α-Reductase Inhibitors

5α-Reductase inhibitors, such as finasteride and dutasteride, are often prescribed to treat conditions like benign prostatic hyperplasia or androgenetic alopecia. While these drugs can be beneficial, their interaction with nandrolone can lead to an increase in androgenic side effects.

In particular, the effectiveness of nandrolone’s anabolic properties might be altered. Users should be cautious, as the balance between therapeutic benefits and side effects can be easily disrupted with concomitant use of these inhibitors.

Antiandrogen Drug Interactions

Antiandrogen medications, including drugs like cyproterone acetate and spironolactone, function by blocking the effects of androgens. Such interactions can lead to several outcomes when combined with nandrolone.

  • Decreased anabolic and androgenic efficacy
  • Potential alteration in the overall hormone profile

These drugs are sometimes employed for conditions that involve hyperandrogenism, but their interaction with nandrolone can complicate treatment regimens. Close monitoring by healthcare providers is essential when both classes of drugs are utilized concurrently.

Author :

Dr. Daniel Martínez, MD, is a highly experienced endocrinologist and nutrition expert with more than two decades of expertise in hormonal and metabolic health. Beyond his work in clinical settings, Dr. Martínez is deeply involved in scientific research, exploring the intersection of endocrinology and performance optimization. He has also contributed as a co-author to a peer-reviewed publication discussing the medical applications of endocrinology in bodybuilding, helping to connect scientific knowledge with athletic performance advancements.

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