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Testosterone is an endogenous steroid hormone that is synthesized from cholesterol in the Leydig cells of the testes, which is made up of 19 carbon atoms. It is also synthesized in theca cells in the ovaries and in the zona reticularis of the adrenal glands.

Testosterone is the quintessential endogenous male hormone, in fact, when a fetus begins to form in the womb, a higher level of testosterone between the fourth and sixth week of gestation will determine if it is going to be a boy, and a lower level a girl.

The endogenous levels of testosterone produced by the testes are controlled by the hypothalamus and the pituitary gland, in response to gonadotropin-releasing hormone from the hypothalamus, while the pituitary gland produces luteinizing hormone in the bloodstream to the gonads, stimulating the production and testosterone release.

Testosterone favors the growth of muscle mass and the increase in muscle strength given its role in protein formation. It also increases bone density and stimulates longitudinal growth, as well as maturation in the case of adolescents, which is why it is highly appreciated by gym enthusiasts.

Testosterone begins to appear during fetal life, where the fetal testes are stimulated by the maternal placenta to produce testosterone. This process will continue up to 10 weeks after birth.

After this period, and throughout the child’s early years, testosterone is barely produced, but between the ages of 19 and 12, with the onset of puberty, a stimulus is generated in the brain that stimulates testosterone production again endogenous testosterone.

Testosterone also has a decisive influence on the brain, stimulating the production of dopamine, which is a powerful natural antidepressant. It also participates in the secretion of acetylcholine, a neurotransmitter that controls memory, keeping it operational. Likewise, cognition, or the ability to perceive and understand the world around us, is highly dependent on testosterone.

The usual values of endogenous testosterone in men are between 10 and 30 nmol/L, while in women it is between 0.6 and 2.5 nmol/L. In women, the decrease in hormonal secretion it occurs abruptly during menopause, while in men the decrease in endogenous testosterone is very noticeable after the age of 40.

Testosterone for gym enthusiasts

Sports doctors Stéphane Bermon and Pierre Yves Garnier published a famous clinical study analyzing the relationship between exogenous testosterone and sports performance in the British Medical Journal, where it has been possible to corroborate that having a high level of exogenous testosterone leads to a hypertrophy of the athlete’s muscle mass, due to its effects on protein anabolism, which in general terms, gives him a physical and mental competitive advantage.

The origin of the use of exogenous testosterone began after World War II in people released from concentration camps, to recover their lost muscles and testicular activity.

The excellent recovery results obtained quickly identified exogenous testosterone as an extremely efficient androgen muscle anabolic agent, from which various 17-alpha-alkylated derivatives for oral use were quickly synthesized, such as methyltestosterone (Methandrén) and fluoxymesterone (Halotestin).

Subsequently, other injectable derivatives with less androgenic capacity were synthesized, and consequently less hepatotoxic, but which maintain their full anabolic capacity, such as nandrolone in the form of fenpropionate and decanoate under the Deca Durabolin brand, and in the form of enanthan under the testosviron brand, including a a combination of propionate, phenylpropionate, isocaproate and decanoate under the Sustanon brand, Methenolone under the Primobolan brand, Oxymetholone under the Anadrol brand, Oxandrolone under the Anavar brand, Stanozolol under the Winstrol brand… among others.

How does testosterone work?

Testosterone is carried by the blood where it circulates for 30 to 60 minutes, to bind to albumin. Once testosterone reaches the cells, it is transformed within them into dihydrotestosterone, which is an anabolic active molecule. Testosterone that is not fixed to cells is quickly transformed in the liver, which is responsible for eliminating those hormones found in the blood, through a process called “aromatization”, by which it transforms the androgen molecule into estradiol. To inhibit the adverse effects of aromatization, post-cycle therapy, HCG or tamoxifen is advised after administration of exogenous testosterone.

Dihydrotestosterone binds to receptors located in the cytoplasm of cells, and from there it goes to the nucleus of cells, where it begins to modify protein synthesis. These proteins, which are synthesized by dihydrotestosterone stimulation, act as regulators of a large number of metabolic reactions and promote skeletal muscle hypertrophy.

Testosterone FAQ

How can a man raise his testosterone level?

Exercising frequently with weight lifting, taking protein supplements, Inhibiting stress and cortisol, and consuming testosterone boosting supplements.

What happens when testosterone is low?

When the level of testosterone is low, there is a reduction in muscle mass, loss of sexual desire, impotence, erectile dysfunction, weakness, breast enlargement and depression.

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