Danazol Steroid profile

Danazol Background and History

Danazol is a synthetic steroid derived from ethisterone that was first developed in the 1960s. It was approved for medical use in the 1970s to treat endometriosis, fibrocystic breast disease, and hereditary angioedema. Danazol works by suppressing estrogen and progesterone levels. It was also used off-label by bodybuilders for its mild anabolic effects. However, serious side effects have limited its usage.

Chemical Structure

The chemical structure of danazol consists of the steroid ethisterone modified with a 2,3-methano group and a 17α-ethynyl group. These modifications make danazol resistant to metabolism and increases its binding affinity for androgen receptors to exhibit steroidal activity similar to testosterone.

Dosages and Cycles

Danazol doses used for medical purposes are typically 200-800mg daily, split into 2-4 doses. When used for physique-enhancement, bodybuilders often took 400-600mg per day for 6-12 week cycles. Stacking with testosterone was common. Higher doses increased toxicity risks.

Effects and Benefits

At anabolic dosages, danazol exhibits moderate effects similar to testosterone. Limited gains of 5-10lbs of lean muscle mass are possible. Strength levels may increase marginally. Other effects like fat loss and increased RBC count are mild. It is considered one of the weaker AAS options.

Side Effects and Health Risks

While Danazol can be effective for certain medical conditions, it is associated with a range of side effects. Common side effects include weight gain, fluid retention, acne, oily skin, and mood changes. It can also cause masculinizing effects in females, such as deepening of the voice, facial hair growth, and clitoral enlargement. Liver toxicity is another potential risk associated with Danazol use. It is important to monitor liver function regularly while using this medication.

Additionally, Danazol may cause changes in lipid profiles, including an increase in LDL cholesterol and a decrease in HDL cholesterol levels. Regular monitoring of lipid levels is recommended during treatment. Danazol is contraindicated in pregnancy due to the potential for fetal harm.

Legal Status

While danazol is approved for certain medical uses, non-FDA approved uses like physique enhancement are considered illegal in the United States. It is a DEA Schedule IV substance only allowed for valid medical treatment. Off-label abuse carries stiff legal penalties.

In summary, danazol is an older steroid that once had limited use for its mild anabolic properties. However, it is now considered obsolete for performance enhancement due to its risks.